Publications (all)
Publikationen Tissue Biology Research Unit
(aus ZORA Zurich Open Repository and Archive)
ZORA Publication List
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Publications
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Safety and efficacy of bio-engineered, autologous dermo-epidermal skin grafts in adolescent and adult burn patients: 1-year results of a prospective, randomized, controlled, multicenter phase IIB clinical trial EClinicalMedicine, 90, 103665. https://doi.org/10.1016/j.eclinm.2025.103665
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Long-term outcomes of a cultured autologous dermo-epidermal skin substitute in children: 5 year results of a phase I clinical trial Journal of Burn Care & Research, 46, 326–334. https://doi.org/10.1093/jbcr/irae150
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scRNA-Seq of Cultured Human Amniotic Fluid from Fetuses with Spina Bifida Reveals the Origin and Heterogeneity of the Cellular Content Cells, 12, 1577. https://doi.org/10.3390/cells12121577
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Life threatening non-accidental burns, pandemic dependent telemedicine, and successful use of cultured Zurich Skin in a neonate – A case report Burns Open, 7, 28–32. https://doi.org/10.1016/j.burnso.2023.03.005
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The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes Scientific Reports, 12, 1944. https://doi.org/10.1038/s41598-022-05309-5
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Human Basal and Suprabasal Keratinocytes Are Both Able to Generate and Maintain Dermo–Epidermal Skin Substitutes in Long-Term In Vivo Experiments Cells, 11, 2156. https://doi.org/10.3390/cells11142156
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Bioprinting and plastic compression of large pigmented and vascularized human dermo-epidermal skin substitutes by means of a new robotic platform Journal of Tissue Engineering, 13, 204173142210885. https://doi.org/10.1177/20417314221088513
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Expanding into the future: Combining a novel dermal template with distinct variants of autologous cultured skin substitutes in massive burns Burns, 5, 145–153. https://doi.org/10.1016/j.burnso.2021.06.002
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First time compassionate use of laboratory engineered autologous Zurich skin in a massively burned child Burns, 5, 113–117. https://doi.org/10.1016/j.burnso.2021.04.004
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Mechanical stimulation induces rapid fibroblast proliferation and accelerates the early maturation of human skin substitutes Biomaterials, 273, 120779. https://doi.org/10.1016/j.biomaterials.2021.120779
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Detrusor bioengineering using a cell-enriched compressed collagen hydrogel Journal of Biomedical Materials Research. Part B, 108, 3045–3055. https://doi.org/10.1002/jbm.b.34633
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Bioengineering of Fetal Skin: Differentiation of Amniotic Fluid Stem Cells into Keratinocytes Fetal Diagnosis and Therapy, 47, 198–204. https://doi.org/10.1159/000502181
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Bioengineering and in utero transplantation of fetal skin in the sheep model: A crucial step towards clinical application in human fetal spina bifida repair Journal of Tissue Engineering and Regenerative Medicine, 14, 58–65. https://doi.org/10.1002/term.2963
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Bio-engineering of fetal cartilage for in utero spina bifida repair Pediatric Surgery International, 36, 25–31. https://doi.org/10.1007/s00383-019-04573-3
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A cultured autologous dermo-epidermal skin substitute for full-thickness skin defects: a phase I, open, prospective clinical Trial in children Plastic and Reconstructive Surgery, 144, 188–198. https://doi.org/10.1097/PRS.0000000000005746
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A simplified fabrication technique for cellularized high-collagen dermal equivalents Biomedical Materials, 14, 041001. https://doi.org/10.1088/1748-605X/ab09c5
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Impact of human mesenchymal cells of different body site origins on the maturation of dermo-epidermal skin substitutes Pediatric Surgery International, 35, 121–127. https://doi.org/10.1007/s00383-018-4383-5
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Induction of angiogenic and inflammation-associated dermal biomarkers following acute UVB exposure on bio-engineered pigmented dermo-epidermal skin substitutes in vivo Pediatric Surgery International, 35, 129–136. https://doi.org/10.1007/s00383-018-4384-4
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Epithelial proliferation in inflammatory skin disease is regulated by tetratricopeptide repeat domain 7 (Ttc7) in fibroblasts and lymphocytes Journal of Allergy and Clinical Immunology, 143, 292-304.e8. https://doi.org/10.1016/j.jaci.2018.02.057
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Genome editing of human primary keratinocytes by CRISPR/Cas9 reveals an essential role of the NLRP1 inflammasome in UVB sensing Journal of Investigative Dermatology, 138, 2644–2652. https://doi.org/10.1016/j.jid.2018.07.016
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Polyisocyanopeptide hydrogels: A novel thermo-responsive hydrogel supporting pre-vascularization and the development of organotypic structures Acta Biomaterialia, 70, 129–139. https://doi.org/10.1016/j.actbio.2018.01.042
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Expression of inflammasome proteins and inflammasome activation occurs in human, but not in murine keratinocytes Cell Death and Disease, 9, 24. https://doi.org/10.1038/s41419-017-0009-4
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Characterization of M1 and M2 polarization of macrophages in vascularized human dermo-epidermal skin substitutes in vivo Pediatric Surgery International, 34, 129–135. https://doi.org/10.1007/s00383-017-4179-z
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The expression pattern of keratin 24 in tissue-engineered dermo-epidermal human skin substitutes in an in vivo model Pediatric Surgery International, 34, 237–244. https://doi.org/10.1007/s00383-017-4198-9
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UVB exposure of a humanized skin model reveals unexpected dynamic of keratinocyte proliferation and Wnt inhibitor balancing Journal of Tissue Engineering and Regenerative Medicine, 12, 505–515. https://doi.org/10.1002/term.2519
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The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma Nature Communications, 8, 1988. https://doi.org/10.1038/s41467-017-01573-6
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Human adipose mesenchymal cells inhibit melanocyte differentiation and the pigmentation of human skin via increased expression of TGF-β1 Journal of Investigative Dermatology, 137, 2560–2569. https://doi.org/10.1016/j.jid.2017.06.027
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Evaluation of cultured human dermal- and dermo-epidermal substitutes focusing on extracellular matrix components: Comparison of protein and RNA analysis Burns, 43, 520–530. https://doi.org/10.1016/j.burns.2016.10.002
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Comparison of in vivo immune responses following transplantation of vascularized and non-vascularized human dermo-epidermal skin substitutes Pediatric Surgery International, 33, 377–382. https://doi.org/10.1007/s00383-016-4031-x
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The effect of wound dressings on a bio-engineered human dermo-epidermal skin substitute in a rat model Journal of Burn Care & Research, 38, 354–364. https://doi.org/10.1097/BCR.0000000000000530
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Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering Journal of the Mechanical Behavior of Biomedical Materials, 69, 85–97. https://doi.org/10.1016/j.jmbbm.2016.12.004
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Successful grafting of tissue-engineered fetal skin Pediatric Surgery International, 32, 1177–1182. https://doi.org/10.1007/s00383-016-3977-z
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Myelinated and unmyelinated nerve fibers reinnervate tissue-engineered dermo-epidermal human skin analogs in an in vivo model Pediatric Surgery International, 32, 1183–1191. https://doi.org/10.1007/s00383-016-3978-y
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About ATMPs, SOPs and GMP: the hurdles to produce novel skin grafts for clinical use Transfusion Medicine and Hemotherapy, 43, 344–352. https://doi.org/10.1159/000447645
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Functional Analysis of Vascularized Collagen/Fibrin Templates by MRI In Vivo Tissue engineering. Part C, Methods, 22, 747–755. https://doi.org/10.1089/ten.TEC.2016.0035
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Visualisation of newly synthesised collagen in vitro and in vivo Scientific Reports, 6, 18780. https://doi.org/10.1038/srep18780
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Characterization of vasculogenic potential of human adipose-derived endothelial cells in a three-dimensional vascularized skin substitute Pediatric Surgery International, 32, 17–27. https://doi.org/10.1007/s00383-015-3808-7
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Collagen hydrogels strengthened by biodegradable meshes are a basis for dermo-epidermal skin grafts intended to reconstitute human skin in a one-step surgical intervention Journal of Tissue Engineering and Regenerative Medicine, 10, 81–91. https://doi.org/10.1002/term.1665
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The influence of stromal cells on the pigmentation of tissue-engineered dermo-epidermal skin grafts Tissue Engineering. Part A, 21, 960–969. https://doi.org/10.1089/ten.TEA.2014.0327
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Characterization of pigmented dermo-epidermal skin substitutes in a long-term in vivo assay Experimental Dermatology, 24, 16–21. https://doi.org/10.1111/exd.12570
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Long-term expression pattern of melanocyte markers in light- and dark-pigmented dermo-epidermal cultured human skin substitutes Pediatric Surgery International, 31, 69–76. https://doi.org/10.1007/s00383-014-3622-7
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Experimental tissue engineering of fetal skin Pediatric Surgery International, 30, 1241–1247. https://doi.org/10.1007/s00383-014-3614-7
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Differential expression of granulocyte, macrophage, and hypoxia markers during early and late wound healing stages following transplantation of tissue-engineered skin substitutes of human origin Pediatric Surgery International, 30, 1257–1264. https://doi.org/10.1007/s00383-014-3616-5
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Tissue-engineered dermo-epidermal skin grafts prevascularized with adipose-derived cells Biomaterials, 35, 5065–5078. https://doi.org/10.1016/j.biomaterials.2014.02.049
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De novo epidermal regeneration using human eccrine sweat gland cells: Higher competence of secretory over absorptive cells Journal of Investigative Dermatology, 134, 1735–1742. https://doi.org/10.1038/jid.2014.30
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Analysis of blood and lymph vascularization patterns in tissue-engineered human dermo-epidermal skin analogs of different pigmentation Pediatric Surgery International, 30, 223–231. https://doi.org/10.1007/s00383-013-3451-0
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Tissue-engineered dermo-epidermal skin analogs exhibit de novo formation of a near natural neurovascular link 10 weeks after transplantation Pediatric Surgery International, 30, 165–172. https://doi.org/10.1007/s00383-013-3446-x
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Bioengineering dermo-epidermal skin grafts with blood and lymphatic capillaries Science Translational Medicine, 6, 221ra14. https://doi.org/10.1126/scitranslmed.3006894
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Tissue engineering of skin: human tonsil-derived mesenchymal cells can function as dermal fibroblasts Pediatric Surgery International, 30, 213–222. https://doi.org/10.1007/s00383-013-3454-x
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Human amniotic fluid derived cells can competently substitute dermal fibroblasts in a tissue-engineered dermo-epidermal skin analog Pediatric Surgery International, 29, 61–69. https://doi.org/10.1007/s00383-012-3207-2
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Tissue engineering of skin for wound coverage European Journal of Pediatric Surgery, 23, 375–382. https://doi.org/10.1055/s-0033-1352529
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“Trooping the color”: restoring the original donor skin color by addition of melanocytes to bioengineered skin analogs. Pediatric Surgery International, 29, 239–247. https://doi.org/10.1007/s00383-012-3217-0
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Optimizing in vitro culture conditions leads to a significantly shorter production time of human dermo-epidermal skin substitutes Pediatric Surgery International, 29, 249–256. https://doi.org/10.1007/s00383-013-3268-x
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Rebuild, restore, reinnervate: do human tissue engineered dermo-epidermal skin analogs attract host nerve fibers for innervation? Pediatric Surgery International, 29, 71–78. https://doi.org/10.1007/s00383-012-3208-1
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Human eccrine sweat gland cells turn into melanin-uptaking Keratinocytes in dermo-epidermal skin substitutes Journal of Investigative Dermatology, 133, 316–324. https://doi.org/10.1038/jid.2012.290
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A new model for preclinical testing of dermal substitutes for human skin reconstruction Pediatric Surgery International, 29, 479–488. https://doi.org/10.1007/s00383-013-3267-y
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Glucose sensing in human epidermis using mid-infrared photoacoustic detection Biomedical Optics Express, 3, 667–680. https://doi.org/10.1364/BOE.3.000667
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Matriderm(®) 1 mm versus Integra(®) Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats Pediatric Surgery International, 28, 171–177. https://doi.org/10.1007/s00383-011-2990-5
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Modified plastic compression of collagen hydrogels provides an ideal matrix for clinically applicable skin substitutes Tissue Engineering. Part C, Methods, 18, 464–474. https://doi.org/10.1089/ten.TEC.2011.0561
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Engineering melanoma progression in a humanized environment in vivo Journal of Investigative Dermatology, 132, 144–153. https://doi.org/10.1038/jid.2011.275
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Novel treatment for massive lower extremity avulsion injuries in children: slow, but effective with good cosmesis European Journal of Pediatric Surgery, 21, 106–110. https://doi.org/10.1055/s-0030-1267234
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Osmotic expanders in children: no filling - no control - no problem? European Journal of Pediatric Surgery, 21, 163–167. https://doi.org/10.1055/s-0030-1270460
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Determining the origin of cells in tissue engineered skin substitutes: a pilot study employing in situ hybridization Pediatric Surgery International, 27, 255–261. https://doi.org/10.1007/s00383-010-2776-1
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Skingineering II: transplantation of large-scale laboratory-grown skin analogues in a new pig model Pediatric Surgery International, 27, 249–254. https://doi.org/10.1007/s00383-010-2792-1
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Skingineering I: engineering porcine dermo-epidermal skin analogues for autologous transplantation in a large animal model Pediatric Surgery International, 27, 241–247. https://doi.org/10.1007/s00383-010-2777-0
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Tissue engineering of skin Burns, 36, 450–460. https://doi.org/10.1016/j.burns.2009.08.016
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Human eccrine sweat gland cells can reconstitute a stratified epidermis Journal of Investigative Dermatology, 130, 1996–2009. https://doi.org/10.1038/jid.2010.83
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Transglutaminases, involucrin, and loricrin as markers of epidermal differentiation in skin substitutes derived from human sweat gland cells Pediatric Surgery International, 26, 71–77. https://doi.org/10.1007/s00383-009-2517-5
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Formation of human capillaries in vitro: The engineering of prevascularized matrices Tissue Engineering. Part A, 16, 269–282. https://doi.org/10.1089/ten.tea.2008.0550
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Markers to evaluate the quality and self-renewing potential of engineered human skin substitutes in vitro and after transplantation Journal of Investigative Dermatology, 129, 480–490. https://doi.org/10.1038/jid.2008.254
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Wege zu einer neuen Haut: Von den zellbiologischen Grundlagen über Tissue Engineering zu einem neuen Hautsubstitut Paediatrica, 20, 57–61. http://www.swiss-paediatrics.org/paediatrica/vol20/n4/pdf/57-59.pdf
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Matriderm versus Integra: a comparative experimental study Burns, 35, 51–57. https://doi.org/10.1016/j.burns.2008.07.018
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Impact of carbon dioxide versus air pneumoperitoneum on peritoneal cell migration and cell fate Surgical Endoscopy, 20(10):1607-1613.